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FORMULATION & EVALUATION OF TRANSDERMAL DRUG DELIVERY SYSTEM OF PARACETAMOL
Siddhant Prasad Thapa*, Om Prakash Sahu, Sumit Sahoo, Seema Kujur, Sital Purty
ABSTRACT A simple and reproducible method was developed for paracetamol by reverse phase high performance liquid chromatography (RR-HPLC), paracetamol was separated on C18 column, particle size, using ortho phosphoric acid buffer with PH of 3.5 at the UV detection of 207nm. Isocratic elution of acetonitile (ACN) and water was used as a mobile phase with various ratios and flows rates, eventually 25:75 v/v CAN and water was being set with the flow rate of 1mL/min. The statistical validation parameters such as linearity, accuracy, precision, inter-day variation were checked, further the limit of detection and limit of quantification of paracetamol concentrations were found to be 120ng/mL and 360ng/mL. Recovery and assay studies of paracetamol were within 99 to 102% indicating that the proposed method can be adoptable for quality control analysis of paracetamol. Keywords: . [Download Article] [Download Certifiate] |