Abstract

DISPOSITION KINETICS AND IMMUNOLOGICAL PROFILE OF TYLVALOSIN IN MOLAR DUCKS

Hanem El-Gendy and Saber El-Hanbally*

ABSTRACT

This study was conducted to assay both pharmacokinetics and the immunological profile of Tylvalosin in healthy Molar ducks. Tylvalosin was administered intravenously and orally at single dose (25mg/kg b.wt.) to determine its concentrations in serum as well as its kinetic profile by using high performance liquid chromatography (HPLC) technique; also it was administered orally twice daily for four consecutive days to determine it’s effect on immune response. Blood samples were collected at 5, 15, and 30 minutes and at 1,2,4,6,8,12 and 24 hrs. After Tylvalosin administered intravenously and orally at single dose (25mg/kg b.wt.), the serum concentration- time curve indicated a two compartment open model. Following a single intravenous injection, distribution half-life (t0.5α) was 0.23 ± 0.03h, volume of distribution (Vdss) was 15.10 ±1.03 L/kg, elimination half-life (t0.5β) was 4.38±0.27 h and total body clearance (CLtot) was 2.16±0.06 l/kg/h. Following a single oral administration, Tylvalosin was absorbed with (T1/2ab) of 0.45±0.04 h with peak serum concentration (Cmax) of 1.42±0.04 μg/ml at (tmax) of 1.48±0.06 h and eliminated with half-life (t0.5el) was 2.96±0.14 h. The systemic bioavailability after oral administration was 83.05 ± 0.68% indicating good absorption of Tylvalosin after oral administration. Tylvalosin decreased the total leukocytic count, lymphocytes, total protein and globulin level due to immunosuppressive effect.

Keywords: Pharmacokinetics, Tylvalosin, Ducks, Bioavailability, Immunity.