Abstract

INTERRELATION OF BIOLOGICAL, RENAL, HEPATIC, HISTOLOGICAL MARKERS AND TREATMENT THERAPY OF EHRLICH ASCITES CARCINOMA IN MICE

Jubran Mohammed Abdulrahman*, Gihan Hosny Abd Elsamie, Samir Ali Abd El- Kaream and Rakhad Alrawi

ABSTRACT

The underlying work was conducted aiming at curing Ehrlich ascites carcinoma tumor implanted to group of mice, using a sonophotodynamic modality in combination with nano-Chl as a sonophoto sensitizer drug. The result revealed that the treatment therapy of intraperitoneal (IP) injection of nano-Chl, then treated with irradiation of 7000Hz IRL, followed by pulsed ultrasound 3 watts for 3 minutes was fast and efficient in the destruction of cancerous cells. It is recommended that future research should focus on improving such therapy through increasing the time of treatment to more that 3 minutes to speed destruction of all cancerous cells. Correlation coefficients among biological variables (Glutathione-S-Transferase Activity (GST), Glutathione Reductase (GR), Catalase Activity (CAT) Total Antioxidant Capacity (TAC), and Superoxide Dismutase Activity (SOD)) were all highly significant positively related (P

Keywords: Nano-Chl, Sonophotodynamic, Serum biological markers, Cancer, Correlation coefficients.