Abstract

ANTIMICROBIAL ACTIVITY AND PHYTOCHEMICAL ANALYSIS OF PHYLLANTHUS NIRURI AND CISSUS QUADRANGULARIS AGAINST HUMAN PATHOGEN

Rupa Guha Nandi*, Jyoti Kiran Bara and Monika Goswami

ABSTRACT

Plants have been an important source of medicine with other qualities for thousands of years. Phyllanthus niruri commonly known as “Bhumi amla” with wide variety of phytochemical and their pharmacological properties is known. Cissus quadrangularis commonly called “Hadjod" is also one of the important medicinal plant. The plant is well known in Ayurveda for its bone healing properties. The present study was aimed at the determination of the antimicrobial effect of Phyllanthus niruri and Cissus quadrangularis. The study revealed that combination of Phyllanthus niruri and Cissus quadrangularis showed potent antimicrobial activity. The aqueous extract, petroleum ether and methanolic extract of the two medicinal plant were subjected to in vitro antimicrobial assay employing against some human pathogen like E.coli, Psuedomonas Species, Aspergillus niger and Aspergillus flavus etc. Zone of inhibition were also determined. Among the plants tested, Phyllanthus niruri was most effective against pathogenic microorganism where as when their extracts were combined, it was found more effective than individual extracts of both the plants. Phyllanthus niruri and Cissus quadrangularis showed that almost all of the chemical constituents are present in them like tannin, alkaloids, saponin, flavonoids, steroids, starch etc.

Keywords: Antimicrobial effect, flavonoids, phytochemical, Phyllanthus niruri, Cissus quadrangularis.