Abstract

A REVIEW ON NOVEL APPROACHES FOR COLON TARGETED DRUG DELIVERY SYSTEMS

Ashish S. Lekurwale*, Vinod M. Thakare, Ujwala N. Mahajan

ABSTRACT

The colon is a site where both local and systemic delivery of drugs can take place. Local delivery allows topical treatment of inflammatory bowel disease. Colon targeted drug delivery system may be following the concept of control or sustained route for drug administration has received more attention. Colon targeted drug delivery system is not only the suitable for delivering the drug to the colon for local treatment but it is also a preferable approach for delivery of protein and peptide and enhance their bioavailability. Treatment can be made effective if the drugs can be targeted directly into the colon, thereby reducing the systemic side effects. This review, mainly compares the primary approaches for CDDS (Colon Specific Drug Delivery) namely prodrugs, pH and time dependent systems, and microbially triggered systems, which achieved limited success and had limitations as compared with newer CDDS namely pressure controlled colonic delivery capsules, CODESTM, and osmotic controlled drug delivery which are unique in terms of achieving in vivo site specificity, and feasibility of manufacturing process.

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