Abstract

EVALUATION OF ANTIOXIDANT ACTIVITY IN VARIOUS MARKETED HEPATIC FORMULATIONS

Raman Yadav*, Anju Rawat and Yesh Kumar

ABSTRACT

Antioxidants are compounds that have capability of either delay or inhibit the oxidation processes. It occur under the influence of oxygen or reactive oxygen species. Antioxidants are compound involved in the defense mechanism of the organism against the pathologies associated condition due to the attack of free radicals. There are several benefits of antioxidants like antioxidants may boost our brain function, antioxidants decreases oxidative stress, antioxidants prevent cancer, promote liver health, treat urinary tract infection, can treat acne, delay aging, can help bodybuilders. Antioxidant prevent the free radical reaction and protect the muscles from being damaged. Vitamin C have great role in tissue repair. The antioxidant activity of the drugs sample and the standard was measured on the basis of the radical scavenging effect of the stable 1, 1-diphenyl-2-picryl hydroxyl (DPPH) free radical activity method. The stable DPPH radical method is a widely used, relatively quick, most accepted and precise method for the evaluation of the free radical scavenging activity of the drug sample. All eight marketed hepatic formulation showed the capacity of scavenging of free radical. The lowest antioxidant activity is shown by Udiliv i.e. 8.97% and silybon shows the highest antioxidant activity i.e. 60.86%.

Keywords: Antioxidant, Free radicals, oxidative stress, DPPH, Reactive oxygen species