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World Journal of Pharmacy and
Pharmaceutical Sciences

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Medical Research and Technology

Impact Factor : 8.025

ICV : 84.65

WJPPS Citation

	All	Since 2019
Citation	5450	3969
h-index	23	20
i10-index	134	84

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WJPPS: NOVEMBER ISSUE PUBLISHED

NOVEMBER 2024 Issue has been successfully launched on 1 NOVEMBER 2024.

Abstract

DEVELOPMENT AND CHARACTERIZATION OF CONTROLLED RELEASE MATRIX TABLET OF TIAGABINE HYDROCHLORIDE

Akib Y. Mansuri*, Dr.Anand K. Patel and Dr. Vishnu M. Patel

ABSTRACT

The aim of the present study was to develop and characterization of the controlled release matrix tablets of tiagabine. Tiagabine is a nipecotic acid derivatives and anticonvulsant medicament used for the treatment of partial seizures in adults and children ≥12 years of age. FTIR studies indicated no interaction between drug and excipients. All the parameters showed good results. The result was found to be that among the nine formulation the Z4 formulation was found to be the best as it shows maximum drug release of 98.96% at 24 hours. It was subjected to accelerated stability studies for one month. The formulation was found to be stable. It concludes that the controlled release matrix tablets of Tiagabine can prepared by direct compression. Among all the formulations (Z1 to Z9) the Z4 formulation was found to be the best formulation. It showed the least of 25.84% drug release within 2 hours.

Keywords: Tiagabine, Controlled Release tablet, Hydroxy propyl methyl cellulose, Polyethylene oxide, Guargum, direct compression.

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