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World Journal of Pharmacy and
Pharmaceutical Sciences

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Medical Research and Technology

Impact Factor : 8.025

ICV : 84.65

WJPPS Citation

	All	Since 2019
Citation	5450	3969
h-index	23	20
i10-index	134	84

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WJPPS Rank with Index Copernicus Value 84.65 due to high reputation at International Level

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WJPPS: NOVEMBER ISSUE PUBLISHED

NOVEMBER 2024 Issue has been successfully launched on 1 NOVEMBER 2024.

Abstract

SYNTHESIS AND ANTI-INFLAMMATORY ACTIVITY SCREENING OF SOME NOVEL PYRAZOLE DERIVATIVES

Pratap Kumar Patra*, Ch. Niranjan Patra, Subasini Pattnaik

ABSTRACT

The Inflammation is a serious health problem in industrialized country due increase in pollution. In the present study a series of new pyrazole clubbed with quinazolinone compounds (7a1-2, 7b1-2) were synthesized and were evaluated for their anti-inflammatory activity by using the model of carrageenan induced mice paw edema in adult albino rat on comparison with standard diclofenac. The maximum antiinflammatory activity was recorded by the compound 7a1 having 65.38% percentage protection of edema followed by compound 7b1 (60.25 %), 7b2 (50 %) & 7a2 (39.74%) anti-inflammatory potential. The compound 7a1 showed more percentage protection of edema than that of standard drug Diclofenac sodium. It has been found that the extent of increase in paw volume reduces significantly up to 3 hrs when compared with solvent control.

Keywords: Anti-inflammatory activity, Carrageenan induced mice paw edema, Diclofenac, Pyrazole, Quinazolinone.

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