Abstract

RESEARCH ARTICLE ON PREPARATION AND IN-VITRO CHARACTERIZATION OF SUSTAINED RELEASE METFORMIN HCL MATRIX TABLETS USING DIFFERENT POLYMERS

Srilatha K. S.*, Savithri T. B. and Kavitha S. K.

ABSTRACT

Metformin hydrochloride is an oral anti-hyperglycaemic drug belongs to BCS class III. Its short biological half life is 3 hrs hence it is an ideal candidate for sustained release formulation. The present investigation was aimed to formulate and evaluate sustained release matrix tablets of metformin hydrochloride using hydrophilic rate retarding polymers Hydroxy propyl methyl cellouse K100M and guar gum by direct compression. From the in-vitro release studies it was found that the optimized formula DF12 containing 10.11% Hydroxy propyl methyl cellouse K100M and 1.29% guar gum as retarding polymers showed a desired release of 97.09% for 12 hrs when compared to that of marketed product. From the results it was found that HPMC K100M and guar gum alone could not control the release effectively for 12 hrs. But the formulation containing combination of HPMC K100M and guar gum in optimized concentration retarded the drug release effectively for 12 hrs. The dissolution data obtained from all the developed formulations were fitted in release kinetics. The optimized best formulation DF12 followed zero order kinetics indicated by higher R2 value than the first order and when fitted in korsemeyer-peppas equation it showed super case II transport diffusion.

Keywords: Metformin hydrochloride, HPMC K100M, Matrix tablet, Sustained release direct compression.