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World Journal of Pharmacy and
Pharmaceutical Sciences

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Medical Research and Technology

Impact Factor : 8.025

ICV : 84.65

WJPPS Citation

	All	Since 2019
Citation	5450	3969
h-index	23	20
i10-index	134	84

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WJPPS Rank with Index Copernicus Value 84.65 due to high reputation at International Level

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WJPPS: NOVEMBER ISSUE PUBLISHED

NOVEMBER 2024 Issue has been successfully launched on 1 NOVEMBER 2024.

Abstract

DEVELOPMENT AND VALIDATION OF UV SPECTROPHOTOMETRIC METHOD FOR ESTIMATION OF OLOPATADINE HYDROCHLORIDE IN BULK AND PHARMACEUTICAL DOSAGE FORM

Zeba Mahamad Hanif Gaibu*, Dr. Mallinath Shankarappa Kalshetti, Shubhangi Sidram Bamgonde, Kaveri Chandrakant Dulange, Neha Ranjeet Gate

ABSTRACT

A simple, precise, accurate, economical and reliable UV spectrophotometric method has been developed for the estimation of Olopatadine hydrochloride in bulk and its tablet dosage form. The drug shows maximum absorption (λmax) at 231 nm in methanol and obeys Beer’s law in the concentration range of 3-15 μg/ml with correlation coefficient (R2=0.999). The accuracy was found to be 97.2-99.6%. Limit of detection (LOD) and limit of quantification (LOQ) were found to be 0.047 μg/ml and 0.144 μg/ml respectively. The relative standard deviation was found to be

Keywords: Olopatadine hydrochloride, UV Spectrophotometer, Method Validation.

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