Abstract

FORMULATION AND EVALUATION OF FLOATING MICROBALLOON OF LEVODOPA AND CARBIDOPA

Sachin Bagde*, Deepak Kumar Gupta, Shelendra Kumar Manglawat, Raju Choukse, Rakesh Patel

ABSTRACT

Floating systems are low-density systems that have sufficient buoyancy to float over the gastric contents and remain in the stomach. After release of drug, the residual system is emptied from the stomach, floating system involving unfilled microspheres or microballoons with excellent buoyant properties. Time-controlled oral drug delivery systems offer several advantages over immediate-release dosage forms. Controlled-release drug delivery systems (CRDDS) provide drug release at a predetermined, predictable, and controlled rate. During the fed state onset of MMC is delayed resulting in slowdown of gastric emptying rate. Superior to single unit floating dosage forms as such microspheres releases drug uniformly and there is no risk of dose dumping.

Keywords: .