Abstract

ANTIHYPERLIPIDEMIC ACTIVITY OF ACACIA NILOTICA PODS EXTRACTS IN TRITON INDUCED HYPERLIPIDEMIC RATS

Shrinivas K. Sarje*, Sneha Sakhare, Kushewati Ingole, Shital Narwde, Shinde Angad

ABSTRACT

Hyperlipidemia is the common and challenging health problem throughout the world. Hyperlipidemia is a key risk factor for cardiovascular disorders (CVD). Since synthetic drugs have shown side clinical importance of herbal drugs in the treatment of CVD has considerable attention in recent years. The present research work was focused on evaluation of Acacia nilotica pods extracts for antihyperlipidemic activity in triton induced hyperlipidemic rats. Acacia nilotica was administered at a dose of 100mg/kg and 200mg/kg per day, to triton induced hyperlipidemic rats. Atorvastatin was used as reference standard. The activity was assessed by estimation of body weight, serum lipid profile etc. The bio-chemical parameters like Total cholesterol (TC), Triglycerides (TG), High density lipoprotein cholesterol (HDL-C), Low density lipoprotein cholesterol (LDL-C), Very low density lipoprotein cholesterol (VLDL-C) were also assessed. The statistical analysis was carried out using ANOVA followed by Tukey test. The graded doses of Acacia nilotica extracts significantly reduced the weight gain pattern of body. The present study demonstrated that Acacia nilotica extracts shows antihyperlipidemic effect.

Keywords: Acacia nilotica, Hyperlipidemia, Triton, Atorvastatin, wistar rats.