Abstract

REVIEW ON TRANSDERMAL DRUG DELIVERY SYSTEM

Sai Datri Arige*, Lakshmana Rao A. and Vinod Kumar V. L.

ABSTRACT

Transdermal drug delivery systems are defined as self contained, discrete dosage forms which, when applied to unbroken skin, deliver the drug through the skin, at a controlled rate to systemic circulation. The transdermal route of administration is recognized as one of the potential route for the local and systemic delivery of drugs. Transdermal patches follow diffusion mechanism for delivery of drugs. Through a diffusion process, the drug enters the bloodstream directly though the skin. Since there is high concentration on the patch and low concentration in the blood, the drug will keep diffusing into the blood, the drug will keep diffusing into the blood for a long period of time, maintaining the constant concentration of drug in the blood flow. TDDS offer many advantages, such as elimination of first pass metabolism, sustained drug delivery, reduced frequency of administration, reduced side effects and improved patient compliance. For the adequate delivery of drug through the transdermal patches can be affected by the different factors. Evolution of transdermal patch is use to ensure its quality, size, time of onset & duration, adhesive property, thickness, weight of patch, moisture of content, uniformity, permeation & toxicological studies.

Keywords: Transdermal drug delivery system, Transdermal patches, Diffusion, Evolution, TDDS.