Abstract

A REVIEW ON NANOCRYSTAL: AS A PROMISING APPROACH FOR TARGETED DRUG DELIVERY SYSTEM

Sagar S. Sontakke*, Prof. Afaque Raza Mehboob Ansari, Parikshit D. Shirure, Naushad N. Mirza, Manmat B. Rumane1 and Aniket S. Katte

ABSTRACT

Nanotechnology will affect our lives tremendously over the next decade in very different fields, including medicine and pharmacy. Transfer of materials into the nanodimension changes their physical properties which were used in pharmaceutics to develop a new innovative formulation principle for poorly soluble drugs: the drug nanocrystals. The drug nanocrystals do not belong to the future; the first products are already on the market. The industrially relevant production technologies, pearl milling and high pressure homogenization, are reviewed. The physics behind the drug nanocrystals and changes of their physical properties are discussed. The marketed products are presented and the special physical effects of nanocrystals explained which are utilized in each market product. Examples of products in the development pipelines (clinical phases) are presented and the benefits for in vivo administration of drug nanocrystals are summarized in an overview. In this present review this new approach is discussed in terms of their introduction, BCS classification, Properties, advantages, Limitation, special Features, Techniques Application and characterization. Nanocrystals are most developing formulations of nanotechnology with several applications in different fields like drug delivery, clinical medicine and research as well as in other varied sciences. SLN are the spherical particles of nanometer range which immersed in water or aqueous surfactant solution either using lipophilic and hydrophilic drug. This review also emphasize on methods to minimize the toxic and overdosing effects of drugs using sophisticated production techniques like homogenization and solvent evaporation. The present review focuses on the utility of Nanocrystals in terms of their advantages, production methodology, characterization and applications. If properly investigated, Nanocrystals may open new vistas in therapy of complex diseases.

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