ASSESSMENTS OF OXIDATIVE STRESS BIOMARKERS IN PATIENTS WITH GYNAECOLOGICAL MALIGNANCY
Suman Gautam, A .A. Mahdi, Ranjana Singh*, Baby Anjum, Seema Mehrotra,M.L.B Bhatt, J.K.Saxena
ABSTRACT
The present study was undertaken in patients of gynaecological
malignancy to evaluate the status of oxidative stress and antioxidant
defence mechanisms. The Protein carbonyl (PC), Total lipid
hydroperoxide (LOOH) and Total thiol (T-SH) levels in patients with
gynaecological malignancy including carcinoma cervix, endometrium
and ovarian were studied. Newly diagnosed women with
gynaecological carcinoma [N=150], 30-75 years of age and agematched
clinically healthy women [N=50] were included in the present
study. Result: Circulating plasma total lipid hydoperoxides and
protein carbonyl levels were significantly [p
Keywords: Hydroperoxidation, gynaecological malignancy, Protein carbonylation, Total thiol.
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