Abstract

FORMULATION AND CHARACTERIZATION OF PIROXICAM LIQUISOLID TECHNIQUE FOR SOLUBILITY ENHANCEMENT

I.N.S.Harsha, D.Lohithasu*, K.Manohar Babu,G.Madhu, K.Lavanya andK.Krishna Swaroop

ABSTRACT

This present study an attempt was made to formulate poorly water soluble drug i.e.,piroxicam to enhance the dissolution rate of piroxicam by liquisolid systems. Based on the solubility studies the polyethylene glycol 400 (PEG400) is chosen as cosolvent, Microcrystalline cellulose (MCC) used as carrier material and Aerosil used as coating material. Liquisolid system is characterized by flow properties , solubility studies in non volatile solvents(hydrophobic carriers), drug content, Fourier transform infra red spectroscopy(FTIR), powder X-ray diffraction(XRD) and in-vitro release evaluation. By using this liquisolid technique, solubility parameter and dissolution rate can be improved. Based on various formulations of liquisolids were prepared by using non volatile solvents or hydrophobic carriers and their effect on dissolution of piroxicam was studied. Conclusion: The liquisolid systems is a novel technique for solubility enhancement and dissolution improvement of low soluble drugs.

Keywords: liquisolid systems (LS), carriers, low soluble drug and non-volatile solvents.