Abstract

FAMOTIDINE LOADED FLOATING BIOMATERIAL GELLAN GUM BEADS IN -VITRO CHARACTERIZATION

*Jogu Sowjanya, B. Rama M. Pharm, phD and M. Swetha M. Pharm

ABSTRACT

Famotidine has been the most broadly utilized drug for the treatment of peptic ulcer for a long time. The present examination concerns the formulation and evaluation of floating tablets of famotidine which after oral administration, to drag out the gastric residence time, increment medicate bioavailability and focus on the gastric ulcer. A gliding drug delivery system was created gellan gum. Every one of the formulations were subjected for preformulation evaluation. After effects of preformulation examines, FTIR, SEM, molecule size and size dissemination, % yield, drug content, buoyancy time, entrapment efficiency, in vitro dissolution and release kinetics. The FTIR Spectra uncovered that, there was no cooperation among polymers and Famotidine. Based on release information of Famotidine plan F5 demonstrated a decent controlled release profile with most extreme ensnarement effectiveness as a result of ideal polymer fixation i.e., 1:3 proportion (Gellan gum) with sodium alginate than other drug: polymer proportions. The invitro dissolution studies for best formulation F5 were fitted in various kinetic models i.e, zero order, first order, Higuchi and korsemeyer-peppas models. optimized formulation F5 demonstrates zero order sedate release with Super case II transport system.

Keywords: Famotidine, Gellan gum, FTIR, SEM.