Abstract

ROLE OF SILYMARIN IN MANAGEMENT OF PEPTIC ULCERIN RATS

El-Sayed M. G.*, ElZorba, H., Sahar S. Abd El-Rahman and Elbanna A. H.

ABSTRACT

Peptic ulcer disease which include gastricand duodenal ulcer is the most prevalent gastrointestinal disorder. Despite medical advances, the management of peptic ulcer and its complications remain a challenge, with high morbidity and death rates for the disease. Milk thistle seeds are rich in flavonolignans silybin (A and B), isosilybin (A and B), silydianin, silychristin, and isosilychristin, as well as the flavonoid, taxifolin.sylimarin has been demonstrated to have beneficial effects in studies of hepatoprotective and possesses antioxidant activity. The present investigation aimed to evaluate the anti-ulcer activity and the possible mechanismsof action ofsylimarin against ethanol induced gastric ulcers using curative models at two dosage level (50 & 100 mg/kg). The obtained results showed that, oral administration of sylimarinfor rats in doses of 50 and 100mg /kg body weight for 7 days post induction of gastric ulcer induce a potent antiulcerogenic activity in a dose dependent manner indicated by significant decrease in ulcer area, ulcer index, ulcer number and score but increased mucus weight and PH. Sylimarin at doses 50&100 mg/kg induced a significant enhancement in the gastric GSH, CAT, SOD levels of ethanol-induced ulcer rats and reduced the elevated level of MDA. The present study, showed that sylimarin restoration of gastric histopathology aberrations and leukocyte influx signifying its potential anti-ulcer actions.

Keywords: Gastric ulcer- SYLIMARIN- curative—Prophylactic – Mechanism.