Abstract

ZINC IODIDE: A MILD AND EFFICIENT CATALYST FOR ONE-POT MULTICOMPONENT SYNTHESIS OF 3-INDOLE DERIVATIVES AND STUDY OF ITS IN-VITRO ANTI-INFLAMMATORY ACTIVITY

Rohit R. Wakodkar, Pravin Kulkarni, Mazahar Farooqui, and Deepak D. Kayande*

ABSTRACT

An efficient and economical method was developed for the synthesis of 3-substituted indole zinc iodide catalysed condensation between aldehyde, malnonitrile and indole. The process was carried out in ethanol at refluxing temperature. This protocol provides broad applications due to its operation simplicity, shorter reaction time and low cost.

Keywords: Zinc iodide, indole, Multicomponent reactions, aldehyde, anti-inflammatory (in-vitro).