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World Journal of Pharmacy and
Pharmaceutical Sciences

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Medical Research and Technology

Impact Factor : 8.025

ICV : 84.65

WJPPS Citation

	All	Since 2019
Citation	5450	3969
h-index	23	20
i10-index	134	84

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WJPPS introducing updated version of OSTS (online submission and tracking system), which have dedicated control panel for both author and reviewer. Using this control panel author can submit manuscript

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WJPPS Impact Factor has been Increased to 8.025 for Year 2024.

WJPPS Rank with Index Copernicus Value 84.65 due to high reputation at International Level

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WJPPS is indexed in Scope Database based on the recommendation of the Content Selection Committee (CSC).

WJPPS: NOVEMBER ISSUE PUBLISHED

NOVEMBER 2024 Issue has been successfully launched on 1 NOVEMBER 2024.

Abstract

EVALUATION OF HEPATOPROTECTIVE ACTIVITY OF SQUALENE ISOLATED FROM ALBIZIA PROCERA AGAINST PARACETAMOL INDUCED HEPATOTOXICITY ON WISTAR RATS

S. Sivakrishnan*, A. Kottai Muthu

ABSTRACT

The aim of this study was to evaluate hepatoprotective activity of squalene isolated from Albizia procera Roxb.(Benth.) against paracetamol induced hepatotoxicity on wistar rats. Paracetamol treatment leads to elevated levels of serum enzymes, non-enzyme markers & lipid profiles and also decreased the serum protein levels. However, treatment with squalene isolated from Albizia procera significantly reversed the above changes compared to the control group as observed in the paracetamol-challenged rats. The results clearly demonstrate that squalene isolated from Albizia procera possesses promising hepatoprotective effects and hence suggests its use as a potential therapeutic agent for protection from paracetamol overdose.

Keywords: Hepatotoxicity, Paracetamol, Albizia procera, Squalene.

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