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FORMULATION AND EVALUATION OF ORAL DISPERSIBLE TABLETS OF LORATADINE BY DIRECT COMPRESSION METHOD
Surendra Prasad Gupta*, Pashupati Bashyal and Laxmi Shrestha
ABSTRACT
New era is an era of novel drug delivery system. Formulation research is oriented towards increasing safety and efficacy of existing drug molecule through novel concept of drug delivery. Oral dispersible tablet (ODT) has become one of the most widely employed commercial products. Among the various drugs that have potentiality to be formulated in ODT forms, Loratadine is one of them which at present widely applied on the formulation of ODT dosage forms. It is the second generation anti-histamine drug that is widely used in the treatment of rhinitis, hay fever and other various allergic conditions like utricaria and contact dermatitis. It forms the part of initial therapy for allergic reactions. In the present work an attempt has been made to formulate, develop and evaluate oral dispersible tablet of Loratadine by using direct compression method with various superdisintegrants like Keywords: Oral Dispersible Tablet, Loratadine, Anti-histamine, Superdisintegrants, Bioavailability. [Download Article] [Download Certifiate] |