Abstract

FORMULATION AND EVALUATION OF TOPICAL GEL FOR ANDROGENIC ALOPECIA

Swapnali S. Mankar*, Dr. Swapnil S. Mankar and Satish Turan

ABSTRACT

Simple topical gel of newer class dosage form is of Finasteride and Terbinafine prepared with polymer Carbapol 934-P combinations with HPMC-K100, solvants used are ethanol and propylene glycol and water. Triethanolamine used to adjust the pH, propyl paraben added as preservatives. These formulations prevent the spread of Tinea capities as well as Androgenic alopecia and increase the hair count. In preformulation studies UV absorption of both drugs carried out, the drug compatibility study was carried out by FTIR. The formulated gel was evaluated by stability parameters like spreadability, extrudability, viscosity, pH, homogeneity, drug content determination, skin irritation test, antifungal activity. Ex-vivo Bioadhesive strength measurement was done of topical gel as compaired to cellophane membrane drug release from fresh goat hairless skin. The In-vitro drug release of Finasteride and Terbinafine carried out from 0 to 8 hours All formulated gel shows proper stability study even flow, clear gel without entrapment of air bubble and adhere long time on the scalp. During UV absorption and drug and drug release study formulation-2 shows maximum absorption at both spectrum and maximum drug release. Hence formulation-2 was the excellent formulation.

Keywords: Finasteride, Terbinafine, Androgenic alopecia, Tinea capities.