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FORMULATION AND EVALUATION OF TOPICAL GEL FOR ANDROGENIC ALOPECIA
Swapnali S. Mankar*, Dr. Swapnil S. Mankar and Satish Turan
ABSTRACT
Simple topical gel of newer class dosage form is of Finasteride and Terbinafine prepared with polymer Carbapol 934-P combinations with HPMC-K100, solvants used are ethanol and propylene glycol and water. Triethanolamine used to adjust the pH, propyl paraben added as preservatives. These formulations prevent the spread of Tinea capities as well as Androgenic alopecia and increase the hair count. In preformulation studies UV absorption of both drugs carried out, the drug compatibility study was carried out by FTIR. The formulated gel was evaluated by stability parameters like spreadability, extrudability, viscosity, pH, homogeneity, drug content determination, skin irritation test, antifungal activity. Ex-vivo Bioadhesive strength measurement Keywords: Finasteride, Terbinafine, Androgenic alopecia, Tinea capities. [Download Article] [Download Certifiate] |