Abstract

ASSESMENT OF DRUG UTILIZATION EVALUATION OF ANTIPLATELETS AND FIBRINOLYTIC AGENTS IN A TERTIARY CARE TEACHING HOSPITAL

Ramanath K. V.* and Shanid A. S.

ABSTRACT

Introduction: Drug utilization pattern study is a powerful exploratory tool to evaluate present trends of drug use and appropriateness of prescriptions. Cardiovascular diseases (CVD) are responsible for about 1/3 of deaths and likely to remain the prevalent eradicator globally. Antiplateletes are most commonly prescribed drugs for ischemic heart disease, cerebrovascular accident and other cardiovascular diseases. Hence the drug utilization of antiplateletes and thrombolytic agents are essential. Methods: A prospective and observational study was conducted in AH&RC for a period of nine months in general medicine department. The data was collected from Patient case sheets/Medication chart and prescriptions after the approval from Institutional Ethical Committee. Results: Among110 patients, 68% were male and 32% were female, whose average age was 65 and 8.2% was alcoholic, 20% was smokers. Among the antiplatelets aspirin (54.5%) was most commonly prescribed. Streptokinase was the common fibrinolytic drug. DDI interactions was observed in 92 patients, in which Mild drug interactions were observed only in 39 patients, 88 were moderate and 12 were major interaction. Total cost of the drugs were more in MI (2700+1817) patient, followed by CCF, COPD with HTN (2685.33+1833.54). Conclusion: Aspirin was the most commonly prescribed antiplatelet drug. Among the fibrinolytics streptokinase was most commonly used. This study conclude that antiplatelets are the most commonly used cardiovascular drugs in different cardiovascular diseases, utilization pattern of these drugs will give knowledge about the rational use of drugs in different disease condition and the cost effective treatment.

Keywords: DUE: drug utilization evaluation, CCF: Congestive cardiac failure, DDI: Drug-Drug interaction, MI: Myocardial infraction, CVD: cardio vascular diseases.