Abstract

REVIEW ARTICLE ON PARKINSON DISEASE

Rabia Choudhary* and Dr. Satish Sharma

ABSTRACT

Parkinson disease is a neurodegenerative disorder characterised by the cardinal symptoms of stiffness, resting tremor, slowness (bradykinesia) and reduction of movement (hypokinesia). It is an aging population and although there have been several significant breakthroughs in terms of the treatment of this debilitating disease, such as drugs levodopa, dopamine [DA] agonists, anticholinergics and surgery (deep brain stimulation, transplants). Parkinson’s disease is a chronic, progressive, neurodegenerative disorder with an estimated prevalence of 31 to 328 per100, 000 people worldwide. It is estimated that more than 1 percent of the population over age 65 are afflicted with Parkinson’s disease, incidence and prevalence increase with age. several models are used in Parkinson disease like neurotoxin models MPTP, 6-OHDA and Pesticides and herbicides models like Paraquat and Rotenone. Antioxidants play a essential role in the prevention or treatment of Parkinson disease, three main antioxidant suppliments are tocopherol, CoQ10, and glutathione.

Keywords: Parkinson Models, MPTP, 6-OHDA, Paraquat, Rotenone, and Anti parkinson drugs.