Abstract

MUCOADHESIVE BUCCAL PATCHES: A REVIEW ON

Ganesh N. Patil*, Vaibhav K. Patil, Sulbha G. Patil, Nilesh P. Salunkhe and Sunil P. Pawar

ABSTRACT

The buccal mucosa has been investigated for local drug therapy and the systemic delivery of therapeutic peptides and other drugs that are subjected to first-pass metabolism or are unstable within the rest of the gastrointestinal tract. The mucosa of the oral cavity presents a formidable barrier to drug penetration, and one method of optimizing drug delivery is by the use of adhesive dosage forms and the mucosa has a rich blood supply and it is relatively permeable. Buccalbioadhesive films, releasing topical drugs in the oral cavity at a slow and predetermined rate, provide distinct advantages over traditional dosage forms for treatment of many diseases. The adhesive properties of such drug delivery platforms can reduce the enzymaticdegradation due to the increased intimacy between the delivery vehicle and the absorbing membrane. However, per oral administration of drugs has disadvantages such as hepatic first pass metabolism and enzymatic degradation within the GI tract, that prohibit oral administration of certain classes of drugs especially peptides and proteins. Transmucosal routes of drug delivery offer distinct advantages over per oral administration for systemic drug delivery.

Keywords: Buccal drug delivery, Oral mucosa, Buccal patches, Mechanism Mucoadhesion, Evaluation.