Abstract

REVIEW ON MICROSPHERES: METHODS OF PREPARATION AND EVALUATION

Dipak A. Patil*, Sandip A. Tadavi, Nilesh P. Salunkhe and Dr. Sunil P. Pawar

ABSTRACT

Microspheres are typically free flow powders consisting of proteins or synthetic polymers which are biodegradable in nature. And ideally having a particle size less than 200μm. Microsphere after ball bearing effects because of their spherical shape. The therapeutic efficacy of microspheres contain drug depends upon their characteristics that can be altered in required terms by altering materials, methods, polymers or techniques used. A Microspheres has its drug dispersed throughout the particle i.e. the internal structure is a matrix of drug and polymeric excipients. It is the reliable means to deliver the drug to the target site with specificity, if modified, and to maintain the desired concentration at the site of interest without untoward effects. Microspheres received much attention not only for prolonged release, but also for targeting of anticancer drugs to the tumor. In future by combining various other strategies, microspheres will find the central place in novel drug delivery, particularly in diseased cell sorting, diagnostics, gene & genetic materials, safe, targeted and effective in vivo delivery and supplements as miniature versions of diseased organ and tissues in the body.

Keywords: Microspheres, Drug delivery, target site, preparation, evaluation, application.