Abstract

EVALUATION OF ANTIDIABETIC POTENTIAL OF MADHURAKSHAK; A POLYHERBAL FORMULATION AGAINST STREPTOZOTOCIN INDUCED DIABETES MELLITUS

Madan S*, Gullaiya S, Sharma D, Kamraj M

ABSTRACT

Several traditional treatment strategies have been recommended in the alternative system of medicine for the treatment of diabetes mellitus. Present investigation was undertaken to evaluate and examine the antidiabetic potential of Madhurakshak(Mdr), a polyherbal formulation containing extracts from twelve different herbs viz., Pterocarpus marsupium, Cinnamomum tamala, Eugenia jambolana, Gymnema sylvestre, Piper nigrum, Azadiracheta indiaca, Trigonella foenumgraecum, Momordica charantia, Phyllanthus emblica, Terminalia chebula, Terminalia belerica and shudh shilajit in streptozotocin ( STZ 40mg/kg i.p. single dose) induced type I diabetic rats. Effects of Madhurakshak Powder (600 mg/kg, oral), Mdr concentrate (300mg/kg, oral) and standard herbal drug Diabecon (250 mg/kg, oral) were evaluated on chronic (28 days) administration in STZ induced diabetic rats. This evaluation was based on various parameters studied which included blood glucose, Liver parameters (creatinine, urea, AST, ALT and ALP), Serum markers (serum triglyceride, cholesterol, LDL, bilirubin, HDL& Total Protein) and histopathological studies. Our results concluded that MdrPowder and Mdr concentrate were both able to depict their antidiabetic potential and were able to bring back the deranged level of liver and serum markers to near normal. This was backed by histopathological studies which revealed the possible beta cell protection potency of this polyherbal formulation.

Keywords: Madhurakshak, Antidiabetic, Polyherbal Formulation, Streptozotocin.