Abstract

PREPARATION AND IN VITRO EVALUATION OF FAMOTIDINE MUCOADHESIVE MICROSPHERES USING DIFFERENT MUCOADHESIVE AGENTS

A. Navaneetha*, A. Sree Gayathri, K. Pushpalatha and Dr. H. Padma latha

ABSTRACT

The present study involves preparation and characterization of mucoadhesive microspheres with famotidine as model drug for prolongation of gastric residence time. Mucoadhesive formulation has been accepted as a process to achieve controlled release and drug targeting. Mucoadhesion is a topic of current interest in the design of drug delivery systems. Mucoadhesive microspheres exhibited a prolonged residence time at the site of application or absorption and facilitate an intimate contact with the underlying absorption surface and thus contribute to improved and/or better therapeutic performance of drugs. In recent years such mucoadhesive microspheres have been developed for oral, buccal, nasal, ocular, rectal and vaginal routes for either systemic or local effects. The microspheres were prepared by Orifice Ionic-Gelation method using mucoadhesive polymers like HPMC (hydroxy propyl methyl cellulose), CMC (carboxy methyl cellulose) MC (methyl cellulose) and a release controlling polymer Sodium alginate. In Vitro drug release studies were performed and drug released evaluated. The effect of polymer concentration on size of microspheres and drug release were observed. The prepared microspheres exhibited prolonged drug release the mean particle size increased as the concentration of sodium alginate increased, as the sodium CMC polymer concentration increases the mucoadhesion increased and the drug release rate decreased at higher concentration of Sodium alginate.

Keywords: Microspheres, famotidine, hydroxy propyl methyl cellulose, carboxy methyl cellulose.