Abstract

PHYTOCHEMICAL SCREENING, IN VITRO PHARMACOLOGICAL PROFILE OF Sauropus androgynous AND ITS CYTOTOXIC ACTIVITY AGAINST HUMAN OVARIAN CANCER CELLS PA1

Devishree T. N.* and Dilip Kumar S.

ABSTRACT

Sauropus androgynous is a shrubby plant having high potential of medicinal properties due to its extensive reservoir of nutraceutical compounds. The purpose of this cogitation was to investigate the phytochemistry of different leaf extracts which are methanol, chloroform and aqueous followed by an analysis of in vitro anti- inflammatory, anti-diabetic, antioxidant, antimicrobial and cytotoxicity effects against Human ovarian carcinoma cell line PA1. The phytochemical screening and in vitro bioactivities reveals the distribution of various metabolites in different extracts quantitatively by estimating their inhibitions. The IC50 value for Human ovarian cancer cell line was 60, 80 and 100μg/ml for methanol, aqueous and chloroform extracts respectively. This utilitarian study involving pharmacological profile would be useful in clinical and medical applications due to its therapeutic potential and this herb can be promoted to serve as a pharmacotherapy for prevalent diseases.

Keywords: Sauropus androgynous, phytochemistry, anti-inflammatory, anti-diabetic, antioxidant, Cytotoxicity.