METHOD DEVELOPMENT OF METFORMIN HYDROCHLORIDE RP-HPLC
Gadipally Saikiran*
ABSTRACT
A simple, specific, accurate and precise Reverse Phase High
Performance Liquid Chromatographic method was developed
metformin hydrochloride in tablet dosage form on RP Kromasil -ODS
C18 using mobile phase as Methanol:orthophosphoric acid (50:50)The
flow rate was 1.0 ml/min and effluent was monitored at 270nm. The
retention time is 2.3 respectively.
Keywords: metformin hydrochloride Reverse Phase High Performance Liquid Chromatography.
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