Abstract

REVIEW ON NATURAL TERATOGENS

Neelmani Chauhan*, J. E. Rachel Nivedita, S. Sravanthi

ABSTRACT

The aim of this study was to present the implications of the use of herbs during pregnancy, pointing out those that should be avoided during this condition because of their abortifacient and/or teratogenic potential. Many poisonous range plants common in the diet of domestic livestock possess teratogenic potential. Some congenital deformities, once thought to be of genetic origin, are now known to be caused by the teratogens of these plants. The period of maternal ingestion required to produce congenital defects varies among plants, from a single dose on one day to prolonged periods of one to two weeks. Knowledge of the duration of maternal ingestion required for the teratogenic effect to be realized has aided in formulating postulates on the mechanism of action. In some instances, the teratogens have been isolated and structurally characterized, permitting further postulation on the mechanism.

Keywords: Teratogens, pregnancy, natural plants, fetus.