Abstract

GASTRORETENTIVE DRUG DELIVERY SYSTEM: A REVIEW

Dr. Prashant S. Malpure, Bapu R. Chavan*, Dr. Avish D. Maru, Jayshree S. Bhadhane, Eknath B. Thakare and Prasad S. Sonawane

ABSTRACT

The most Advantageous approach of the Gastro-retentive drug delivery systems improves the drug bioavailability and patient compliance by increasing the gastric residence time and controlling the drug release.These include floating/low density system, swelling and expanding system, bioadhesive/mucoadhesive system, high density system, magnetic system and raft forming system. The present review addresses briefly about the gasroretentive drug delivery system its include physiology of the stomach, objectives, needs, criteria, factors affecting, advantages and disadvantages, approaches, marketed product, evaluation parameters, applications of Gasrtoretentive drug delivery system. In order to understand various physiological difficulties to achieve gastric retention, we have summarized factorsinfluencing gastric retention and also included various strategies for gastric retention. Gastroretentive drug delivery system has become leading methodology in site specific orally administered controlled release drug delivery system. Various drugs, which are unstable in alkaline pH, soluble in acidic pH, having narrow absorption window, site of action specific to stomach can be developed by using this technique.

Keywords: Gastro-retentive drug delivery system, Approaches of gastro-retentive system, Application, Evolution parameters.