Abstract

A REVIEW ON SOLID LIPID NANOPARTICLES NOVEL APPROACH FOR DRUG DELIVERY

Sangita Talke*, Rajendra Dafal, Dr. M.R Sherkar and Sonal Phule

ABSTRACT

Solid lipid nanoparticles is a novel drug delivery system which is used to encapsulate the cationic and anionic drug. This drug delivery system developed to increase bioavailability of lipophilic drug in a systemic circulation. This also used to encapsulate the drug those are degrade in to stomach environment. This drug delivery system targets the lymphatic system because it contains lipids. Different methods are used to prepare solid lipid nanoparticles like hot homogenization technique, cold homogenization technique, ultrasonication, solvent emulsification evaporation techniques, microemulsion based method, supercritical fluid technology, solvent injection method etc. Different characterization of solid lipid nanoparticles also carried out like particle size, Zeta potential, Morphology of solid lipid nanoparticles, percent entrapment efficiency, Drug loaging capacity, percent drug release, X- ray diffraction etc. Solid lipid nanoparticles administered different route. Like oral, parenteral, rectal, nasal, ocular, topical etc.

Keywords: Solid lipid nanoparticles. Lipophilic, Hydrophilic, lyophilization.