Abstract

REVIEW ON IN SITU GEL A NOVEL NASAL DRUG DELIVERY SYSTEM

Manashi P. Valavi*, Sandip A. Tadavi, Azam Shaikh and Sunil P. Pawar

ABSTRACT

The oral route is most preferred and common technique for oral administration of drug in the body, but due to certain limitation such as absorption of drug, hepatic first-pass metabolism, drug targeting to particular organ can cause problem for administration through oral route. To overcome these types of problem as well as for improvement of drug safety and efficiency a novel approach is developed for delivery of drug i.e. In-situ Nasal Drug Delivery System. Nasal route is suitable for those drugs whose oral administration is problematic due to gastric irritation. The present review focused on anatomy of nasal system and criteria required of drug candidate to prepare a gel i.e. In-situ gel. Approaches towards various formulation of in-situ gel with respect to temperature, pH and physiochemical condition. The main role of polymers like Carbopol-934, PEG, Sodium alginate, Poloxamer, Pectin, Cellulose etc. in body, absorption of drug by various methods. The in-situ gel forming polymeric formulations offer several advantages like sustained and prolonged action in comparison to conventional drug delivery systems. Various evaluation parameters which is consider during preparation of in-situ gel.

Keywords: In-situ drug delivery, Polymers, Approaches, Formulation, Evaluation.