Abstract

SONOCHEMICAL SOLVENT-FREE AND ANTIBACTERIAL EVALUATION OF SULPHONAMIDE 1, 2-BENZIZOXAZOLE DERIVATIVES.

*Sayyed Hussain, Shivaji Jadhav, Ayesha durrani, Megha Rai

ABSTRACT

Most of the diseases in the current scenario are found to be infections caused by microbes like bacteria, fungi etc. many antibiotics have been discovered till date for treatment of such diseases but most of them associated with super-infection development of resistance, destruction of normal non-pathogenic bacterial flora and selectivity toxicity like aplastic anaemia, kidney damage etc. The present study based upon preparation of antibiotics with high potency, specificity and less toxicity. Sulphonamide and Benzisoaxazol are widely distributed in nature and they have been shown to have very interesting pharmacological activities like antibacterial. When two biological active moieties present in single molecule generally has increased potency. Hence in the present study the mixture of Chloro-sulphonylcompound and concentrated ammonia irradiated under ultrasonic irradiation for short time period (8-10 min.) at temperature 45-500C to get 3-alkyl -5-sulphonamido-1, 2- benzisoxazoles

Keywords: Sulphonamide, Benzisoaxazol ultrasonic irradiation, solvent-free, antibacterial