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World Journal of Pharmacy and
Pharmaceutical Sciences

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Medical Research and Technology

Impact Factor : 8.025

ICV : 84.65

WJPPS Citation

	All	Since 2019
Citation	5450	3969
h-index	23	20
i10-index	134	84

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WJPPS Rank with Index Copernicus Value 84.65 due to high reputation at International Level

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WJPPS: NOVEMBER ISSUE PUBLISHED

NOVEMBER 2024 Issue has been successfully launched on 1 NOVEMBER 2024.

Abstract

EVALUATION OF SAPONINS FROM SESBANIA SESBAN L. MERR FOR ITS ANTIFERTILITY EFFECT IN FEMALE ALBINO RATS

Payal Rahul Dande*, Chandrakant Bonde, Nancy Pandita

ABSTRACT

Saponins are natural glycoside compounds that exhibit structuredependent biological activities. Present study was undertaken to evaluate the saponins from Sesbania sesban leaf, at a dose of 100mg/kg and 200mg/kg, for possible antifertility activity in female albino rats of normal estrus cycle. The animals were observed for its effect on estrous cycle, implantation and further on abortive activity. The vaginal cornification & uterine weight assay was carried to determine the estrogenic activity of the saponin extract. Saponins from the leaves of Sesbania sesban showed highly significant dose dependent anti-implantation (56% & 86%) and abortifacient (75% and 92%) activity at both 100 mg/kg and 200 mg/kg (P

Keywords: Sesbania sesban, Saponin, antifertility, anti-implantation, Abortifacient, Estrogenic activity, estrous cycle.

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