Abstract

ASSOCIATION OF ABNORMAL CERVICAL CYTOLOGY WITH HIV POSITIVITY AMONG WOMEN OF REPRODUCTIVE AGE GROUP

Supriti Kumari*, Sunita Malik, Harsha Shailesh Gaikwad, Nitin Tyagi, Gaurav Anand, Mausumi Bharadwaj, Suresh Dhambani7, Prabal Rajvanshi and Bhaskar Charana Kabi

ABSTRACT

HIV infection causes impaired cell mediated immunity which in turn is responsible for persistent HPV infection & increase risk for abnormal PAP Test.[1,2] HIV seropositivite women if affected by high risk HPV types it progresses rapidly to precancerous lesion and then cervical cancer as compared to seronegative women. Frequent screening and elimination of precancerous lesion under cervical cancer prevention program is the only way of blocking the oncogenesis. There are 110 types of HPV infections known and out of which only half infect the genital tract. According to IARC WHO classification only 13 types are carcinogenic and rest 7 are possibly carcinogenic. Out of carcinogenic ones are HPV -16,18,31,33,35,39,45, 51, 52, 56,58, 59 and 68.[3] Immunosuppresed state of HIV prevents host from effectively eliminating HPV from the target tissues and make it prone for CIN and precursor lesion. The relationship among human immunodeficiency virus, Human pappiloma virus, and development of Cervical Intraepithelial Neoplasia are undoubtedly complex and incompletely understood. Present study is an attempt to find out the prevalence and relationship of abnormal cervical cytology and HPV infection in HIV positive women.

Keywords: .