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SYNTHESIS OF 4-[5-(4-NITROPHENYL)-4, 5-DIHYDRO-1H-PYRAZOL-3-YL]-3-(2, 4-DICHLOROPHENYL) SYDNONE AND ANTICANCER SCREENING AGAINST 60 TUMOR CELL LINES
Sachin K. Bhosale*, Shreenivas R. Deshpande, Rajendra D. Wagh and Nirmala V. Shinde
ABSTRACT This research work seeks to synthesize of novel mesoionic compound 4-[5-(4-nitrophenyl)-4, 5-dihydro-1H-pyrazol-3-yl]-3-(2, 4-dichlorophenyl) sydnone, Ia containing sydnone moiety to transform antitumor molecule. Compound synthesized by cyclization of 4-[1-oxo-3-(4-nitrophenyl)-2-propenyl]-3-(2,4-dichlorophenyl)sydnone, I (sydnonyl-substituted α, β-unsaturated ketone) with hydrazine hydrate. Compound Ia was characterized by spectral study and evaluated against 60 human cancer cell lines for in vitro anticancer activity and was found to have greater anticancer activity than standard vincristine sulphate against some specific cell lines. Further structural modification of the molecule might lead to development of potent antitumor molecules. Keywords: . [Download Article] [Download Certifiate] |