Abstract

ALTERNATIVE APPROACH TO CURRENT MANAGEMENT STRATEGIES IN ULCERATIVE COLITIS

Pranita Ramchandra Kale* and Dr. Mitali Milind Bodhankar

ABSTRACT

The colon is a site where both the local and systemic delivery of drug takes place. Ulcerative colitis is a chronic idiopathic inflammatory disease of GIT which affects mucosal lining of the colon. Problem related to the colonic formulation can be overcome by optimizing various therapeutic strategies. This review compares primary approach for colon targeted drug delivery, some newer approaches including possible polymers used. It triggers the use of some innovative therapeutic strategies for the development of formulation for colon targeted diseases. The limitations of traditional colon targeted delivery system may be overcome by understanding these better approaches having the careful understanding of the clinical particularities of disease. The future management of ulcerative colitis appears promising as new promising therapies continue to evolve. The therapeutic avenues which are thought out of the box may provide better treatment and quality of life for patient with this disabling disease and it could foster the development of future avenues for translational research.

Keywords: Ulcerative colitis, new therapeutic approaches, polymers.