Abstract

ENHANCEMENT OF SOLUBULITY OF PROPIOMAZINE BY PELLETIZATION

A. Aroon, B. Jayanthi* and K. Satyanarayana

ABSTRACT

The present search engrossed on the preparation and evaluation of delayed release pellets of Propiomazine using a different grade of polymers like HPMC 5CPS, PEG 6000 as a sustained released polymer. Propiomazine is an antihistamine blocking H1 receptors, it is used to treat both negative and positive symptoms of schizophrenia, acute mania with bipolar disorder, agitation, and psychotic symptoms in dementia. pellets are multiparticulate dosage form which was formed by the agglomeration of fine powdered excipient and drugs together that leads to the formation of small free flowing spherical or semi spherical particles. The result of the pellets were within the limits which indicated good flow potential for the prepared pellets. Drug-loaded pellets exhibited spherical shape with uniform and smooth coating. Based on the result, Trail 8 coating level formulations are suitable for the successful delivery of the drug into the lower part of intestine and colon. From the present work, it can be concluded that the prepared drug delivery system can be used for Propiomazine drug.

Keywords: Propiomazine, pellets.