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  • WJPPS MARCH ISSUE PUBLISHED
  • MARCH 2019 Issue has been successfully launched on 1 March 2019

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Abstract

SOLUBILITY ENHANCEMENT OF POORLY WATER SOLUBLE DRUG IRBESARTAN BY SELF EMULSIFYING DRUG DELIVERY SYSTEM

D. Mounica*, Dr. M. Sunitha Reddy, Mohammad Fazal Ul Haq and K. Anie Vijetha

ABSTRACT

The objectives of the present investigations were to optimize concentration of oil, surfactant and co-surfactant by psedoternary phase diagrams and to develop a stable formulation of self emulsifying lipid formulations (SELFs)in order to enhance the dissolution rate of poorly soluble Irbesartan (IRB) by SELFs. Pseudo ternary phase diagrams were constructed to identify the self emulsifying region. Self emulsifying formulations were prepared using PEG 600 as surfactant, capryol 90 as co-surfactant and rose oil/olive oil as oil in various proportions. SELFs were formulated and evaluated for drug content, infrared spectroscopy (FTIR), zeta potential analysis, particle size analysis, in vitro dissolution study and in vitro diffusion study. Optimal formulation of Irbesartan SELFs were successfully developed in this work. The study illustrated that potential use of SELFs dispense liquid soluble drug by oral route.

Keywords: Irbesartan, PEG 600, Capryol 90, rose oil, FTIR studies, In vitro drug release studies.


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