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Abstract

STUDYING PHARMACOTECHNOLOGICAL ASPECTS AND STABILITY OF “ORTOF-S” TABLETS

*Kh. M. Yunusova and M. Sh. Jaloliddinova

ABSTRACT

Biopharmaceutical methods for evaluating the quality of drugs include methods for studying the kinetics of dissolution of medicinal substances from various dosage forms, especially oral solid dosage forms (tablets, granules, dragees, capsules, powders), since, often with their absorption, the dissolution rate of the active substance is much less than the speed suction, and then dissolution becomes the determining factor of bioavailability. General requirements for determining the dissolution rate were introduced in the USP XIX (1970) and are retained in subsequent editions (USP XX-XXIII). In the last XXIII edition of the United States Pharmacopeia, the quality of more than 600 oral dosage solid dosage forms is assessed by individual dissolution tests. In 1983, Dissolution was introduced in the UK pharmacopoeia (BP XIX), and in addition to the German Pharmacopoeia (DAV X 1992), in the French, Japanese and European pharmacopoeias. This indicator is widely used in regulatory documents of pharmaceutical companies. This indicator is widely used in regulatory documents of pharmaceutical companies. In 1985, the "dissolution" index was introduced in the second volume of the GF XI edition (a section of the general article "Tablets"), which allowed to more objectively evaluate the quality of solid dosage forms. To study the rate of dissolution of medicinal substances from tablets, powders, dragees, capsules and other solid dosage forms, devices such as a "rotating basket" and a "rotating blade" are used, more rarely a "rotating bulb" device. The results of research in the field of the development of tablets “ORTOF-S” are presented. Pharmacotechnological aspects were studied and the conditions and shelf life of recommended tablets were determined.

Keywords: Tablets, solubility, pharmacological aspects, accelerated aging, biopharmacy. INTRODUCTION The prerequisite for the emergence of biopharmacy as a science has become numerous facts of therapeutic non-equivalence of the same dose of drug substance. Biologic


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