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  • WJPPS MARCH ISSUE PUBLISHED
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Abstract

THE SUBSTANTION OF THE TABLET MASS “AMBROL” COMPOSITION CHOICE FOR TABLETIZING

Z. Kh. Abdijalilova* and Kh. M. Yunusova

ABSTRACT

Non-narcotic drugs are divided into two main groups. First group includes drugs of central action for instance, butamiratome, glaucine, ledin, pentoxiverin, okseladin and folkodinom; second group includes drugs that have peripheral effects, such as benpropyrin, butiodine, levodropropizin and other remedies. We aimed to study substantiate choice of optimal composition and technology of Ambrol tablets. More than 25 tablet formulations, differing in nature and amount of excipients, were studied. Compositions No.1 and No.2 contained microcrystalline cellulose in an amount from 5% to 10%. Composition No.3 contained 0.08% of aerosil. Compositions No. 4-6 differed in the ratio of lactose and starch, respectively). The remaining mixtures had the same composition, but differed in preparation technology. We found that from solutions of binders (potato starch, methylcellulose, polyvinyl pyrrolidone, sodium carboxymethyl cellulose), the most suitable for a tablet mass is a 5% starch solution in an amount of 8% by weight. It is shown that the tablets have satisfactory performance: disintegration (10.1 ± 0.32) min., Abrasion (99.22%) and compressive strength (75.9 ± 3.45) N.

Keywords: Ambrol; non-narcotic drugs; ambroxol; tablet mass; flowability; microcrystalline cellulose.


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