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  • WJPPS JANUARY ISSUE PUBLISHED
  • JANUARY 2019 Issue has been successfully launched on 1 January 2019

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  • Its our Pleasure to Inform you that WJPPS Impact Factor has been increased from 6.647 to 7.421 due to high quality Publication at International Level

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Abstract

A NOVEL SYNTHESIS OF CEFIXIME FROM 7-AMINO-3-VINYL CEPHALOSPORANIC ACID (7-AVCA)

Nguyen Khanh Tan and Doan Ngoc Nhuan*

ABSTRACT

The present invention relates to simple and easy process for the preparation of cefixime. 7-amino-3-vinyl cephalosporanic acid (7-AVCA) is reacted with 2-mercapto-1,3-benzothiazolyl-(Z)-2-(3-aminothiazol-4-yl)-2-(methoxy carbonyl)-methoxyimino acetate (MICE) in tetrahydrofuran and water mixture at 0-4oC in the presence of triethanolamine. The novel feature of this study was the use of triethanolamine replaced triethylamine in the activation reaction between 7-AVCA with MICE. The results showed that, cefixime has high purity (HPLC purity: 97%) and total yield 66% in the reaction time of 1.5 hours (less than 30 minutes with previous process).

Keywords: 7-AVCA; MICE; cefixime methyl ester; cefixime.


[Full Text Article]

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