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*B. Raja Sankar, R. Saravanan, Jalaiah M. and Dhachinamoorthi D.,


The overall prevalence of dyslipidemia in India in 2013 was 10 % to 73 %. The prevalence of hyperlipidemia is more in females (33.2 %) than in males (32.4). On an average 32.8 % population is suffering from hyperlipidemia. The objective of the present study is to prepare and evaluate the microspheres of simvastatin. Simvastatin microspheres were prepared by ionotropic gelation method using polymers. The simvastatin beads were successfully formulated by ionic gelation technique by using TPP as a curing agent. The formed beads were developed nearly spherical shape with rough surface with slight pores present along the surface which was confirmed by SEM studies. The FTIR, DSC and XRD studies were conducted and given confirmation that there will be chance of getting interaction among used all excipients. The average size of wet uncoated bead was 2.23 ± 0.19 mm. On drying the size reduced drastically to 0.60 ± 0.09 mm.On particle size studies it was clearly indicates that as the amount of chitosan increases particle size also increases simultaneously. i.e. maximium size were found to be 830 μm in batch D. In entrapment efficiency studies, 68 % was observed in batch D. On basis of invitro data it was clearly indicates that as the concentration of chitosan increases, the rate of drug release was delayed and produces zero order pattern release of the drug.

Keywords: Simvastatin, microbead, ionic gelation technique.

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