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  • WJPPS NOVEMBER ISSUE PUBLISHED
  • NOVEMBER 2018 Issue has been successfully launched on 1 November 2018

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  • Its our Pleasure to Inform you that WJPPS Impact Factor has been increased from 6.647 to 7.421 due to high quality Publication at International Level

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Abstract

IN SILICO STUDIES ON DENGUE AND SWINE FLU (INFLUENZA A) VIRAL PROTEINS WITH SELECTED MURRAYA KOENIGII LEAVES CONSTITUENTS

Bhavya M., Ramya M., Anushree S., Archana S., Smriti Chawla and *Balasubramanian Sathyamurthy

ABSTRACT

Murraya koenigii belongs to family Rutaceae. The leaves of Murraya koenigii are used as herbs in Ayurvedic medicine. They are believed to possess anti-diabetic, anti microbial, anti inflammatory properties. The GCMS results showed the presence of 5 compounds in Murraya koenigii with a wide variety of biological activities. The comparative study of both 2 structural and 5 non-structural proteins for dengue along with 7structural and 2 non-structural proteins for Swine flu virus was carried out through In Silico methods. In this study we examined the binding affinities of 5 ligands with 14 proteins of both viruses. By our virtual screening and molecular docking result, we found that the 1,5 -Diformyl-2,6-Dimethoxy-Anthracene had the highest binding affinities with all the 14 proteins and we also predicted the binding site amino acid residues and the type of hydrogen bonding.

Keywords: Molecular docking, Dengue virus, Swine flu virus, Murraya koenigii, Hydrogen bond.


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