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  • WJPPS NOVEMBER ISSUE PUBLISHED
  • NOVEMBER 2018 Issue has been successfully launched on 1 November 2018

  • WJPPS Impact Factor
  • Its our Pleasure to Inform you that WJPPS Impact Factor has been increased from 6.647 to 7.421 due to high quality Publication at International Level

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  • WJPPS Rank with Index Copernicus Value 84.65 due to high reputation at International Level

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Abstract

AN EFFICIENT SYNTHESIS FOR EMPAGLIFLOZIN (AN INHIBITOR OF SGLT-2)

Sureshbabu Jayachandra, Madhuresh Kumar Sethi*, Vipin Kumar Kaushik, Vijaya Krishna Ravi, Jayaram Pothani, P. G. J. Naidu and Purbita Chakraborty

ABSTRACT

Empagliflozin (5) is a promising candidate in SGLT2 inhibitors. An efficient synthetic process consisting usage of two novel intermediates namely [(5-Bromo-2-chlorophenyl) {4-[(3S)-tetrahydrofuran-3-yloxy] phenyl} methyl [Compound 9] and 1-C-[4-chloro-3-(methoxy{4- [(3S)-tetrahydrofuran-3-yloxy]phenyl} methyl) phenyl]- α -Dglucopyranose [Compound 12] has been developed to produce compound 5. This manuscript describes the comprehensive experimentation of this innovative and scale-up with ease synthetic route.

Keywords: .


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