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Samriti Sharma*, Patial Aman, Rana Malvika and Bhandari Neeraj


In the present study, an attempt has been made for the formulation of gastro retentive floating tablets of Valsartan (VAL) using solid dispersion method, one of the most successful techniques to improve dissolution rate of poorly aqueous soluble drugs. Valsartan (VAL) is a potent, highly selective and orally active antihypertensive drug belonging to the family of angiotensin II type 1 receptor antagonists. VAL has much greater affinity for the angiotensin II type 1 (AT1) receptor than for the angiotensin II type 2 (AT2) receptor, thereby relaxing blood vessels and causing them to widen, which lowers blood pressure and improves blood flow. Moreover, it belongs to BCS class-II owing to its poor solubility and high permeability and hence has poor oral bioavailability about 25%. The main purpose of this investigation was to increase the solubility and dissolution rate of VAL by preparing its solid dispersions (SDs) with PVP K30 and mannitol as carriers using solvent evaporation method. Solid dispersions (SDs) and Physical mixtures (PMs) of VAL were prepared in various proportions (1:1, 1:2, 1:3, 1:4, 1:5 and 1:6). Prepared SDs and PMs were optimized for solubility studies, percent drug content and percent dissolution rate studies. The floating tablets containing SDs of VAL were evaluated for uniformity of weight, hardness, friability, drug content, in vitro buoyancy and dissolution studies. The study revealed that, floating tablets using SDs of VAL with PVP K30 can enhance its solubility and dissolution rate.

Keywords: Solid Dispersions (SDs), Physical mixtures (PMs), Valsartan (VAL), Polyvinyl pyrrolidone (PVP), mannitol.

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