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  • WJPPS NOVEMBER ISSUE PUBLISHED
  • NOVEMBER 2018 Issue has been successfully launched on 1 November 2018

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Abstract

KINETICS AND MECHANISM OF OXIDATION OF AMITRIPTYLINE HYDROCHLORIDE DRUG BY CHLORAMINE-T IN ALKALINE BUFFER MEDIUM: A SPECTROPHOTOMETRIC APPROACH

Fathyah Omar Abdulsalam Imbarik and Asha Iyengar*

ABSTRACT

Kinetics of oxidation of amitriptyline hydrochloride drug (AMT) by chloramine-T (CAT) in alkaline buffer medium (9.3) at 306 K has been investigated spectrophotometrically at λmax378 nm. The reaction showed first-order dependence on [CAT] and [AMT] o and inverse fractional-order dependence on [OH-] and [PTS]. Stoichiometry of the reaction was found to be 1:1 with respect to the substrate and oxidant respectively. The oxidation products were identified by spectral analysis. Variation of ionic strength had no effect on the rate. Addition of p-toluene sulphonamide (PTS) retarded the rate of the reaction. Activation parameters have been computed. Probable mechanism and the relevant rate law have been deduced for the observed kinetic results.

Keywords: Amitriptyline hydrochloride, CAT, oxidation-kinetics, alkaline medium.


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