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Elizabeth Wilson Baby*, Aleena Prakash, Akbar Sharooque V., Shalin Elsy Varghese, Apollo James and T. Sivakumar


Glanzmann thrombasthenia is a rare autosomal recessive bleeding disorder due to the absence of glycoprotein IIb/IIIa. Prolonged untreated or unsuccessfully treated hemorrhages are life threatening. It is estimated to affect one in one million individuals in worldwide. The symptoms of Glanzmann thrombasthenia usually begin at birth or shortly thereafter. Purpura, epistaxis, gingival hemorrhage, and menorrhagia are main features and gastrointestinal bleeding and hematuria are less common. Women with GT often also have unusually heavy menstrual bleeding, irregular uterine bleeding, and excess bleeding in childbirth. We present a case of 17 year old female patient was presented with the heavy menstrual bleeding for ten days. The patient had abdominal pain, history of giddiness easy fatigability and loss of weight. Based on bleeding time and flow cytometry. Patient was diagnosed as Type II Glanzmann thrombasthenia. The management done for the patient was blood transfusion and antifibrinolytic. Immediate control of bleeding and found good response.

Keywords: Glanzmann thrombasthenia, Platelet function analyzer, Light transmission aggregometry.

[Full Text Article]

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